Behavior of Adult Human Skin in Organ Culture
نویسندگان
چکیده
منابع مشابه
Replication of varicella-zoster virus in human skin organ culture.
Varicella-zoster virus (VZV) infection is restricted to humans, which hinders studies of its pathogenesis in rodent models of disease. To facilitate the study of VZV skin tropism, we developed an ex vivo system using human fetal skin organ culture (SOC). VZV replication was analyzed by plaque assay, transmission electron microscopy, and histology. The yield of infectious VZV from SOC increased ...
متن کاملEpithelial cell invasion of the stroma in human skin organ culture.
Invasion of the surrounding tissue by malignant epithelial cells is a complex process. It involves degradation of basement membrane and stromal connective tissue elements and movement of tumor cells into and through the partially-degraded matrix. While the process of tumor cell invasion has been extensively studied in simple two-dimensional or three-dimensional assay systems, it is difficult to...
متن کاملTime course and spacial distribution of UV effects on human skin in organ culture.
Apoptosis plays an important role in eliminating cells from populations when cells have been exposed to UV irradiation and damaged. Studies of cells in culture have provided some details of the mechanisms involved when stress response genes act after exposure to UV irradiation and other environmental stresses. However, little is known about the responses of intact sections of human skin growing...
متن کاملSynthesis of glycosaminoglycan in adult human articular cartilage in organ culture from patients with rheumatoid arthritis.
Hyaline cartilage was obtained from patients undergoing synovectomy of the knee joint for rheumatoid arthritis. Eroded cartilage from beneath the invading pannus and relatively normal cartilage from the same joint were maintained in organ culture for three days. During the first 48 hours in culture the explants were exposed to 35SO4 in the medium. The equivalent layers of normal and eroded cart...
متن کاملMaintenance of normal, metaplastic, and dysplastic states of adult human bronchial mucosa in organ culture.
SUMMARY Bronchial mucosa was obtained from 10 patients undergoing lobectomy (8 for squamous bronchogenic carcinoma) and from 13 patients examined by bronchoscopy. Randomly chosen mucosal patches were incubated with tritiated thymidine and fixed as fresh samples, while others were labeled and fixed after 5 to 15 days of maintenance in organculture.Histological andautoradiographic observations in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1968
ISSN: 0022-202X
DOI: 10.1038/jid.1968.14